Primary Cell ADCP Assay Formats

True ADCP for mAb development

ADCP (antibody-dependent cellular phagocytosis) is an immune defence mechanism in which a cell is engulfed by effector cells of the immune system following targeting by an antibody. ADCP activity is mediated through a diverse range of different effector cells including monocytes, macrophages, dendritic cells or neutrophils with antibody Fc binding arising through different classes of Fcγ receptors.

As with ADCC and CDC cytotoxicity, many therapeutic antibodies and antibody-like proteins can harness and direct ADCP activity towards cell types that express the antigen to which they're directed but for a long time, effector function characterisation of biosimilars has almost exclusively focused on the role of ADCC and CDC with little focus on ADCP activity using primary effector cells. This has changed and biosimilar molecules for which effector modality is possible, ADCP characterisation is required towards the end of clinical development.

Experts in Primary Cell ADCP

Our experts have an unparalleled understanding of the functional requirements of antibodies and are industry leaders in the characterisation of effector function of biosimilarand NBE molecules alike. We have established robust and highly accurate primary cell ADCP assay formats demonstrating activity via CD32 and CD64, using genotyped donors. We provide ADCP characterisation services for the following biosimilar molecules.

Adalimumab (Humira)
Bevacizumab (Avastin)
Denosumab (Prolia)
Etanercept (Enbrel)
Golimumab (Simponi)
Infliximab (Remicade)
Rituximab (Rituxan/MabThera)
Obinutuzumab (Gazyva)
Pertuzumab (Perjeta)
Tocilizumab (Actemra)
Trastuzumab (Herceptin)
Ustekinumab (Stelara)
Ipilimumab (Yervoy)

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Custom ADCP Development Services

With proprietary technology, cell line development capabilities, internal know-how and access to a wide range of primary cell types, we can develop industry-leading ADCP assays across a wide range of different formats to support your molecule at all stages of development.

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