ADCC, ADCP and Trogocytosis

ADCC, ADCP and trogocytosis are immune defence mechanisms that many therapeutic antibodies and antibody-like proteins can harness

ADCC (antibody-dependent cellular cytotoxicity)

Antibody Analytics has developed a revolutionary approach and offers services based upon a proprietary advanced ADCC platform technology. Using novel cell lines and approaches we have eliminated the issues associated with traditional performance of ADCC assays and are able to provide elegant methods that measure target cell death with varying levels of biological relevance and sensitivity, all with unprecedented levels of performance and consistency.

ADCP (antibody-dependent cellular phagocytosis) using primary cells

Our experts have an unparalleled understanding of the functional requirements of antibodies and are industry leaders in the characterisation of effector function of biosimilars. We have established robust and highly accurate primary cell ADCP assay formats demonstrating activity via CD32 and CD64, using genotyped donors. With proprietary technology, cell line development capabilities, internal know-how and access to a wide range of primary cell types, we can develop industry-leading ADCP assays across a wide range of different formats to support your molecule at all stages of development.

Trogocytosis

Rituximab, a therapeutic antibody used to treat chronic lymphocytic leukemia, recognises the CD20 molecule expressed by tumour cells. However, using too much of the antibody results, in part, from the removal of rituximab-CD20 complexes from the tumour cell surface by monocytes through trogocytosis. Trogocytosis is involved in the transfer of molecules between cells or to cells to which the cell is conjugated via the exchange of plasma membrane fragments.

With proprietary technology, cell line development capabilities, internal know-how and access to a wide range of primary cell types, we can develop industry-leading assays across a wide range of different formats to support your molecule at all stages of development.

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