Binding Analysis

Antibody Analytics delivers industry leading binding analysis using a range of platforms, proprietary cell lines and primary cell expertise

Regardless of the monoclonal antibody's (mAb's) mechanism of action, the affinity for the target molecule is an essential characteristic requiring thorough understanding.

At Antibody Analytics, our dedicated scientists provide a range of methodologies to develop this understanding, through:

Direct binding assessments
Implementing competition assay formats
Developing cell-based assessments to transmembrane antigens.

The recognition of an antigen by an antibody-based therapeutic candidate is fundamental to its efficacy as a drug product. Antigens can be soluble factors in the extracellular milieu, or receptor proteins expressed on the surface of a targeted cell type. mAb drugs can function by:

Induction of intracellular cell signalling pathways
Ligand or receptor antagonists
Target for cell death via the adaptive immune response or target with cytotoxic agents.

For more details on our approaches to binding analysis or to discuss assay development, please click here to contact us