Exhausted T-cell assays can significantly improve developer's understanding of the fight against cancer.
T-cell exhaustion is a state of T-cell dysfunction that arises during cancer and other chronic diseases. It is defined by sustained expression of inhibitory receptors and poor effector function. In cancer, exhaustion hinders the optimal control of tumours. Although the pathways involved still need to be fully defined, there have been advances in T-cell exhaustion analysis which are helping to clarify the underlying causes of this state of differentiation and also suggest promising therapeutic opportunities.
Exhausted T-cells have been involved in the pathology of cancer and chronic viral infections. Antibody Analytics are establishing an in vitro model for the generation of exhausted T-cells based on repeated stimulation.