T-cell activation assays allow developers to rapidly identify T-cell modulators
T-cells play a critical role in cell-mediated immunity and can bring about long-term, antigen-specific, effector and memory responses. Scientists have developed a plethora of immunotherapy approaches aimed at inducing and engineering T-cell responses, which have emerged as promising solutions for the treatment of disease like cancer. T-cell activation is initiated by engagement of the TCR/CD3 complex, and the co-stimulatory receptor CD28. Co-stimulation of these receptors on the cell surface of T-cells leads to intracellular signaling events.