WE ARE

ANTIBODY ANALYTICS

EXHAUSTED

T CELL ASSAY

Antibody analytics have developed an in vitro model that mimics the effects of the tumour suppressive microenvironment. Recreating the T cell phenotypes frequently observed in a cancer setting

Whilst expressing high levels of checkpoint molecules, our exhausted T cells have diminished functional capacity in terms of cytokine production and cytotoxic potential
With flexible assay set-ups, you can choose from a range of assay readouts based on your scientific needs
A tried and tested platform ideal for assessing the mechanism of action of checkpoint inhibitors, co-stimulatory agonists, bispecifics and small molecules

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MIXED LYMPHOCYTE

REACTION (MLR)

MLRs are incredibly versatile assays and are a great way to investigate any aspect of T cell activation. Our customers have access to a variety of assay set-ups to suit their needs

Using our pre-screened donors, Antibody Analytics offer greater confidence in method design and execution
Offering a variety of assay formats, allows our customers to tailor our platform based on their requirements and chosen assay endpoints
By understanding the importance of demonstrating a high level of sensitivity, specificity and reproducibility within our assay systems, customers can rest assured the delivery of high-quality data

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T CELL MEDIATED

CYTOTOXICITY

The biological activity of T cell engaging molecules such as bispecific antibodies can be determined using Antibody Analytics’ T cell mediated cytotoxicity platform

Using a wide range of assay designs, we are able to support early screening activities using primary cells all the way through to a highly reproducible and robust lot release methods
Customers can receive real-time assay readouts to better understand their molecule’s ability to induce cell death using our xCELLigence systems
Using our pre-screened donors, Antibody Analytics offer greater confidence in method design and execution

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CYTOKINE

RELEASE

Our cytokine release assays can help you predict some of the immunotoxicities which may be associated with your drug candidate

Using a rational assay design and screening at an early stage of the discovery phase should enable you to reduce the potential immunotoxicity of your molecules
With access to a range of donors and multiplex formats (Luminex), our assay provides you with a wealth of information on multiple cytokines from multiple donors
Bespoke service which will allow us to design an assay format to suit you and your team

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T REG

SUPPRESSION

A number of therapeutics are are being developed to target Treg function with the hope that such molecule design will improve efficacy

Antibody Analytics offer a fully customisable approach that can be readily adapted to address your scientific questions
Treg suppression can be expressed in terms of inhibition of proliferation, and we can also provide cytokine release measurements and phenotyping for activation markers
Our expert immunologists will work closely with you to design the best and most appropriate system to measure Treg function

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Do you require a Beautiful Bioassay? Check out some of our most popular methods

Featured Assays

EXHAUSTED
T CELL ASSAY

T cell exhaustion is a state of T cell dysfunction that arises during cancer and other chronic diseases. It is defined by sustained expression of inhibitory receptors and poor effector function.

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Let us help advance your therapeutics. See some of the ways we can support

Featured Assays

MIXED LYMPHOCYTE
REACTION (MLR)

MLR assays can take a variety of formats that should first be defined and optimised based on the requirements and the endpoints of the assay.

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T CELL MEDIATED
CYTOTOXICITY

Our capabilities allow us to support early screening activities all the way through to the development of lot release potency assay methods.

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CYTOKINE
RELEASE

In a results-driven manner, our expert immunologists can work with you to develop further immunological assays to interrogate the data arising from the cytokine release assay.

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T REG
SUPPRESSION

Our assay is readily adaptable to address your scientific questions. The T cell population to be suppressed can be selected from PBMCs, pan-T cells, CD4+ or CD8+ T cells as required.

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GOT A QUESTION?
GET IN TOUCH

Can’t find what you are looking for?
Benefit from our bioanalytical support

Speak to the biophysics team about off the shelf and bespoke assays to support binding analysis throughout drug development
Speak to our leading immunologists about approaches to better understand how your drug interacts with the immune system
Speak to our bioassay experts for advice and support in designing robust and reproducible methods that will give greater confidence in decision making

Let's talk

Let us help advance your therapeutics. See some of the ways we can support

Featured Assays

Antibody Analytics Ltd.

BioCity Scotland, Bo’ness Road,
Newhouse, Lanarkshire, ML1 5UH

Email: info@antibodyanalytics.com
Tel: +44 (0) 1698 534450