WE ARE

ANTIBODY ANALYTICS

    EXHAUSTED

    T CELL ASSAY

    Antibody analytics have developed an in vitro model that mimics the effects of the tumour suppressive microenvironment. Recreating the T cell phenotypes frequently observed in a cancer setting

     

    • Whilst expressing high levels of checkpoint molecules, our exhausted T cells have diminished functional capacity in terms of cytokine production and cytotoxic potential
    • With flexible assay set-ups, you can choose from a range of assay readouts based on your scientific needs
    • A tried and tested platform ideal for assessing the mechanism of action of checkpoint inhibitors, co-stimulatory agonists, bispecifics and small molecules

    MIXED LYMPHOCYTE

    REACTION (MLR)

    MLRs are incredibly versatile assays and are a great way to investigate any aspect of T cell activation. Our customers have access to a variety of assay set-ups to suit their needs

     

    • Using our pre-screened donors, Antibody Analytics offer greater confidence in method design and execution
    • Offering a variety of assay formats, allows our customers to tailor our platform based on their requirements and chosen assay endpoints
    • By understanding the importance of demonstrating a high level of sensitivity, specificity and reproducibility within our assay systems, customers can rest assured the delivery of high-quality data

    T CELL MEDIATED

    CYTOTOXICITY

    The biological activity of T cell engaging molecules such as bispecific antibodies can be determined using Antibody Analytics’ T cell mediated cytotoxicity platform

     

    • Using a wide range of assay designs, we are able to support early screening activities using primary cells all the way through to a highly reproducible and robust lot release methods
    • Customers can receive real-time assay readouts to better understand their molecule’s ability to induce cell death using our xCELLigence systems
    • Using our pre-screened donors, Antibody Analytics offer greater confidence in method design and execution

    CYTOKINE

    RELEASE

    Our cytokine release assays can help you predict some of the immunotoxicities which may be associated with your drug candidate

     

    • Using a rational assay design and screening at an early stage of the discovery phase should enable you to reduce the potential immunotoxicity of your molecules
    • With access to a range of donors and multiplex formats (Luminex), our assay provides you with a wealth of information on multiple cytokines from multiple donors
    • Bespoke service which will allow us to design an assay format to suit you and your team

    T REG

    SUPPRESSION

    A number of therapeutics are are being developed to target Treg function with the hope that such molecule design will improve efficacy

     

    • Antibody Analytics offer a fully customisable approach that can be readily adapted to address your scientific questions
    • Treg suppression can be expressed in terms of inhibition of proliferation, and we can also provide cytokine release measurements and phenotyping for activation markers
    • Our expert immunologists will work closely with you to design the best and most appropriate system to measure Treg function

    WE ARE

    ANTIBODY ANALYTICS

    Do you require a Beautiful Bioassay? Check out some of our most popular methods

    EXHAUSTED
    T CELL ASSAY

    T cell exhaustion is a state of T cell dysfunction that arises during cancer and other chronic diseases. It is defined by sustained expression of inhibitory receptors and poor effector function.
    Let us help advance your therapeutics. See some of the ways we can support

    MIXED LYMPHOCYTE
    REACTION (MLR)

    MLR assays can take a variety of formats that should first be defined and optimised based on the requirements and the endpoints of the assay.

    T CELL MEDIATED
    CYTOTOXICITY

    Our capabilities allow us to support early screening activities all the way through to the development of lot release potency assay methods.

    Want to keep up to date with R&D advances at Antibody Analytics? Sign up to our Science First newsletter.

    CYTOKINE
    RELEASE

    In a results-driven manner, our expert immunologists can work with you to develop further immunological assays to interrogate the data arising from the cytokine release assay.

    T REG
    SUPPRESSION

    Our assay is readily adaptable to address your scientific questions. The T cell population to be suppressed can be selected from PBMCs, pan-T cells, CD4+ or CD8+ T cells as required.

    GOT A QUESTION?
    GET IN TOUCH

    Can’t find what you are looking for?
    Benefit from our bioanalytical support

    • Speak to the biophysics team about off the shelf and bespoke assays to support binding analysis throughout drug development
    • Speak to our leading immunologists about approaches to better understand how your drug interacts with the immune system
    • Speak to our bioassay experts for advice and support in designing robust and reproducible methods that will give greater confidence in decision making

    Reason for Enquiry

    Let us help advance your therapeutics. See some of the ways we can support

    Antibody Analytics Ltd.

    BioCity Scotland, Bo’ness Road,
    Newhouse, Lanarkshire, ML1 5UH

    Email: info@antibodyanalytics.com
    Tel: +44 (0) 1698 534450

    Contact Us
    close slider

    Product of Interest